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Effects of Berberine on blood glucose levels
Of all studied effects, one of the most significant was Berberine’s blood glucose regulating potential. During a Chinese clinical study course, Berberin’s implications have been studied on Type 2 Diabetes conditions throughout 4 years period, between 2007 and 2011. During this trial, it has been sufficiently as well as scientifically proven that 12 weeks of Berberine treatment could persistently regulate the blood glucose level and significantly improve the IR/PCOS conditions. .
According to this clinical trial, it was concluded, that besides its hyperglycaemia reducing attributes, Berberine was able to compensate dyslipidaemia occurring during diabetes conditions, therefore its fat-reducing effect is also remarkable. Dyslipidaemia is a certain lesion, as being one of the major cause of unjustified obesity and large scale fat deposition in the body. Indeed, Dyslipidaemia is resulted of lipodystrophy – disturbed fat metabolism – when the level of fats are reaching a significantly higher value to normal. In most cases, dyslipidaemia is the cause of yo-yo effect, and this lesion is the background for uncontrollable obesity processes. Thus, Berberine successfully demonstrated to offset Dyslipidaemia. A comparison of Berberine vs other blood glucose reducing drugs has also been disclosed in this publication, for example comparing it with Metformin, which is the formula that has been prescribed in the highest number up until today, for women suffering in IR/PCOS caused lesions. Berberine per se, demonstrated to be more effective than Metformin and, in addition, the greatest advantage of Berberine, is, that it works its way of efficacy without causing physical symptoms and discomfort feeling as Metformin does. Berberine’s hypoglycaemic action (blood glucose lowering effect) is a proven fact, however, Berberine’s versatility can be well characterized and proved by results of clinical studies; besides the already mentioned treatment ability of dyslipidaemia, its positive effects on HbA1C (one major parameter examined at diabetes conditions) as well as its co-benefits on cholesterol levels. All these benefits can be proved with research based evidences. [2-7].
Interactions with other drugs
Taking Berberine in its own is absolutely harmless and has neither produced any major, nor more moderate or even mild side effects at any patients involved in the research trials, however, Berberine’s concurrent use of certain pharmaceutical compositions may be risky.
DO NOT apply Berberine with macrolide antibiotics like Azithromycin and Clarithromycin.
IMPORTANT: Be sure to read the document on possible side effects.
In order to demonstrate the most effective biological comparison of Berberine, daily taking of 3 capsules is recommended. Neither more, nor less. 3 capsules daily – in the morning, at noon, and in the evening, each time, preferably after meals. [19-20].
Summary Applying Berberine as a supplement, in particular is strongly recommended for patients in IR / PCOS and type 2 diabetes (with type 2 diabetes making up about 90% of the cases). Berberine is recommended as well to those suffering from insulin problems, or, for any reason whatsoever targeted to lower their higher than normal blood sugar (glucose) level. On the basis of carried out researches, Berberine was able to lower the cholesterol level in the blood. As Berberine perfectly regulates the body’s insulin secretion, treats dyslipidaemia, and thus fat metabolism in the body, therefore being very effective in reducing the percentage of body fat (weight loss).
90 percent of the publications that examines Berberine were done within the past 6 years, therefore due to the uptodate research results as well as the representative size of study groups demonstrated credible evidences of Berberine’s efficacy.
Berberine was administered throughout 12 weeks in each case, taken daily a dose of 1000-2000 mg in multiple smaller serves throughout the day. Major adverse effects were not diagnosed at all, however, it is definitely not recommended to use Berberine in combination with macrolide antibiotics. Caution should be used when taking Berberine concomitantly with other medicines, as it may be risky. Before usage, it is certainly recommended to consult your physician.
- Dong, H., et al., Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternate Med, 2012. 2012: p. 591654.
- Derosa, G., et al., Effects of berberine on lipid profile in subjects with low cardiovascular risk. Expert Opin Biol Ther, 2013. 13(4): p. 475-82.
- Perez-Rubio, K.G., et al., Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metab Syndr Relat Disord, 2013. 11(5): p. 366-9.
- Yan, H.M., et al., Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. PLoS One, 2015. 10(8): p. e0134172.
- Yang, J., et al., Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. Evid Based Complement Alternat Med, 2012. 2012: p. 363845.
- Zhang, H., et al., Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism, 2010. 59(2): p. 285-92.
- Zhang, Y., et al., Treatment of type 2 diabetes and dyslipidaemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab, 2008. 93(7): p. 2559-65.
- Bae, S. and Y. Yoon, Anti-adipogenic activity of berberine is not mediated by the WNT/beta-catenin pathway. Phytother Res, 2013. 27(6): p. 937-43.
- Pham, T.P., J. Kwon, and J. Shin, Berberine exerts anti-adipogenic activity through up- regulation of C/EBP inhibitors, CHOP and DEC2. Biochem Biophys Res Commun, 2011. 413(2): p. 376-82.
- Huang, C., et al., Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun, 2006. 348(2): p. 571-8.
- Zhou, J. and S. Zhou, Berberine regulates peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in diabetic adipocytes. Eur J Pharmacol, 2010. 649(1-3): p. 390-7.
- Zhou, L., et al., Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes. Biochim Biophys Acta, 2011. 1812(4): p. 527- 35.
- Zhang, Z., et al., Berberine activates thermogenesis in white and brown adipose tissue. Nat Commun, 2014. 5: p. 5493.
- Hu, Y., et al., Lipid-lowering effect of berberine in human subjects and rats. Phytomedicine, 2012. 19(10): p. 861-7.
- Sola, R., et al., Effects of poly-bioactive compounds on lipid profile and body weight in a moderately hypercholesterolemic population with low cardiovascular disease risk: a multicenter randomized trial. PLoS One, 2014. 9(8): p. e101978.
- Wu, X., et al., Effects of berberine on the blood concentration of cyclosporine A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol, 2005. 61(8): p. 567-72.
- Xin, H.W., et al., The effects of berberine on the pharmacokinetics of cyclosporine A in healthy volunteers. Methods Find Exp Clin Pharmacol, 2006. 28(1): p. 25-9.
- Liu, C.S., et al., Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia, 2016. 109: p. 274-82.
- Maeng, H.J., et al., P-glycoprotein- mediated transport of berberine across Caco-2 cell monolayers. J Pharm Sci, 2002. 91(12): p. 2614-21.
- Pan, G.Y., et al., [Inhibitory action of berberine on glucose absorption]. Yao Xue Xue Bao, 2003. 38(12): p. 911-4.
Portion Size: 1 capsule
Daily portions size: 3 capsules
Portions Per Container: 180
Daily portions per Container: 60
1 capsule Berberine 500 mg Coptis Teeta Extract (Standardized To 8% Berberine) 500 mg Berberine 40 mg
- Berberine Hydrochloride
- Anti-Caking Agent (Magnesium stearat, Silica)
- Bulking Agent (Microcrystalline Cellulose)
- Capsule Shell [Gelatin, Colour (Titanium Dioxide)